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Alpha Diagnostic 自身免疫检测试剂盒
更新时间：2020-07-16
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---------- 自身免疫病检测试剂盒
背景简介
自身免疫抗体是机体在非正常状态下，由机体自身免疫系统分泌的针对机体自身蛋白的抗体。比如：系统性红斑性狼疮疾病产生的抗体。自身抗体产生的原因有很多，具体机理还有待研究。多数学者认为：一些自身抗体的产生是由于遗传因素和环境因素共同作用的结果，比如：一些病毒性疾病或长期在处于有毒化学毒素下，都可以导致自身免疫疾病。自身免疫疾病源与机体对自身体内或组织产生免疫应答。换句话说，免疫系统将机体自身的物质误认为病原。这主要局限于一些特定组织：（比如：甲状腺）。自身免疫疾病的治疗主要依赖于免疫调节药物用于降低免疫应答。
自身免疫疾病对机体的伤害程度取决于自身抗体作用的的器官或组织和器官特异性的自身抗体导致的紊乱程度。那些只对单一器官作用自身抗体导致的自身免疫疾病很容易发现，因为这类疾病常常伴有系统的病症。比如：甲状腺机能亢进和桥本氏甲状腺炎。由自身免疫抗体导致的系统性功能紊乱，往往很不易被察觉。自身抗体可通过ELISA 方法检测。患者可能有针对不同抗原的自身抗体。用于自身免疫疾病研究的动物模型有很多。已经发现的：18个自身免疫基因簇中有9个基因簇与相应的动物模型在序列上高度保守。动物模型被广泛应用于人自身免疫疾病的研究，包括：多发性硬化症、糖尿病、风湿性关节炎、系统性红斑狼疮。通过人为诱导、自然的以及遗传操作的各种动物模型被用于研究自身免疫疾病和相应的药物研究。
美国Alpha Diagnostic International公司拥有用于检测不同种属的自身免疫抗体的ELISA 检测试剂盒，包括：小鼠、大鼠、猴及人。
主要的自身免疫抗体和相关物及对应的自身免疫疾病：
自身抗原 | 英文名称 | 疾病 |
抗核抗体 | Anti-SSA/Roautoantibodies
| 系统性红斑狼疮、新生儿心肌梗死、干燥综合征 |
Anti-SSA/Roautoantibodies | 干燥综合征 | |
Anti-centromere antibodies
| CREST综合征 | |
Anti-neuronal nuclear antibody | 眼阵挛 | |
Anti-dsDNA
| 系统性红斑狼疮 | |
Anti-Jo1
| 炎性肌病 | |
Anti-RNP
| 混合型结缔组织病 | |
Anti-Smith
| 系统性红斑狼疮 | |
Anti-topoisomerase antibodies
| 系统性硬化病 | |
Anti-histone antibodies
| 系统性红斑狼疮 | |
抗肌动蛋白抗体 | Anti-actin antibodies
| 乳糜泻病 |
抗循环瓜氨酸蛋白抗体 | anti-CCP (cyclic citrullinated protein) | 类风湿性关节炎 |
狼疮抗凝物 | Lupus anticoagulant
| 系统性红斑狼疮 |
抗磷脂综合征 | ||
抗中性粒细胞抗体 | Anti-neutrophil cytoplasmic antibody (cANCA/pANCA)
| 韦格纳肉芽肿病 |
脉管炎 | ||
类风湿因子 | Rheumatoid factor | 类风湿性关节炎 |
抗平滑肌抗体 | Anti-smooth muscle antibody
| 慢性自身免疫性肝炎 |
抗线粒体抗体 | primary biliary cirrhosis | 原发性肝硬化 |
甲状腺过氧化物酶 | thyroid peroxidase(microsomal)
| 桥本氏甲状腺炎 |
促甲状腺激素受体 | Graves' disease | 格雷夫斯病 |
骨氨酸脱羧酶/胰岛素 | glutamic acid decarboxylase (GAD)/Insulin | I型糖尿病、多发性硬化症 |
自身抗原 | 中文名称 | 英文名称 | 货号 |
Anti-ssDNA
| 人抗单链DNA抗体检测试剂盒 | Human anti-ssDNA IgG ELISA Kit | 3115 |
小鼠抗单链DNA Ig's (total (A+G+M)抗体检测试剂盒 | Mouse Anti-ssDNA Ig's (total (A+G+M) ELISA Kit | 5310 | |
小鼠抗单链DNA IgG检测试剂盒 | Mouse Anti-ssDNA IgG-specific ELISA Kit | 5320 | |
小鼠抗单链DNA IgM检测试剂盒 | Mouse Anti-ssDNA IgM-specific ELISA Kit | 5330 | |
大鼠抗单链DNA IgG检测试剂盒 | Rat Anti-ssDNA IgG-specific ELISA Kit | 650-330-DSN | |
猴抗单链DNA IgG检测试剂盒 | Monkey Anti-ssDNA IgG-specific ELISA Kit | 650-340-DSN | |
Anti-dsDNA | 人抗双链DNA IgG检测试剂盒 | Human anti-dsDNA IgG ELISA Kit | 3100 |
人抗双链DNA IgM检测试剂盒 | Human anti-dsDNA IgM ELISA Kit | 3105 | |
人抗双链DNA IgA检测试剂盒 | Human anti-dsDNA IgA ELISA Kit | 3110 | |
小鼠抗双链DNA总抗体检测试剂盒 | Mouse Anti-dsDNA Ig's (Total A+G+M) ELISA Kit | 5110 | |
小鼠抗双链DNA IgG检测试剂盒 | Mouse anti-dsDNA IgG-specific ELISA Kit, | 5120 | |
小鼠抗双链DNA IgA检测试剂盒 | Mouse anti-dsDNA IgA-specific ELISA Kit | 5120-A | |
小鼠抗双链DNA Ig G1检测试剂盒 | Mouse anti-dsDNA IgG1-specific ELISA Kit | 5120-1 | |
小鼠抗双链DNA Ig G2a检测试剂盒 | Mouse anti-dsDNA IgG2a-specific ELISA Kit | 5120-2a | |
小鼠抗双链DNA IgG2b检测试剂盒 | Mouse anti-dsDNA IgG2b-specific ELISA Kit | 5120-2b | |
小鼠抗双链DNA IgG3检测试剂盒 | Mouse anti-dsDNA IgG3-specific ELISA Kit | 5120-3 | |
小鼠抗双链DNA IgE3检测试剂盒 | Mouse anti-dsDNA IgE-specific ELISA Kit | 5120-E | |
小鼠抗双链DNA IgM检测试剂盒 | Mouse anti-dsDNA IgM-specific ELISA Kit | 5130 | |
大鼠抗双链DNA IgG检测试剂盒 | Rat anti-dsDNA IgG-specific ELISA Kit | 650-130-DDN | |
猴抗双链DNA IgG检测试剂盒 | Monkey Anti-dsDNA IgG ELISA Kit | 670-100-DNM |
自身抗原 | 中文名称 | 英文名称 | 货号 |
Anti-Nuclear Antibodies (ANA or ENA) | 人抗核抗体检测试剂盒 | Human Anti-Nuclear Antibodies (ANA) ELISA Kit | 3200 |
小鼠抗核抗原总抗体检测试剂盒 | Mouse Anti-Nuclear Antigens (ANA/ENA) Ig's (total (A+G+M) ) ELISA Kit | 5210 | |
大鼠抗核抗原IgG检测试剂盒 | Rat Anti-Nuclear Antigens (ANA/ENA) IgG-specific ELISA Kit | 650-230-ANA | |
猴抗核抗原IgG检测试剂盒 | Monkey Anti-ANA (Anti-nuclear Antigens/ENA) IgG ELISA Kit | 670-110-ANM | |
Anti-SSA/Ro (Sjogren Syndrome A) | 人抗干燥综合征A 抗原IgG检测试剂盒 | Human anti-SS-A (60 Kda/Ro IgG ELISA Kit | 3210-SSA |
人抗干燥综合征A 抗原IgG总抗体检测试剂盒 | Mouse Anti-SSA/Ro Ig's (total (A+G+M) ELISA Kit | 5710 | |
Anti-SSB/La ((Sjogren Syndrome B) | 人抗干燥综合征B 抗原IgG检测试剂盒 | Human anti-SS-B/La IgG ELISA Kit | 3220-SSB |
Anti-Sm (Smith antigen) | 人抗史密斯抗原IgG检测试剂盒 | Human Anti-Smith antigen (Sm) IgG ELISA kit | 3300-100-SMG |
小鼠抗史密斯抗原总抗体检测试剂盒 | Mouse Anti-Sm Ig's (total (A+G+M) ELISA Kit | 5405 | |
Anti-RNP (ribonucleoprotein) | 人抗核糖核蛋白IgG检测试剂盒 | Human Anti-RNP (RNP-70) IgG ELISA kit | 3300-120-RNG |
小鼠抗核糖核蛋白总抗体检测试剂盒 | Mouse Anti-nRNP Ig's (total (A+G+M) ELISA Kit | 5410 | |
Anti-Sm/RNP | 人抗史密斯抗原/核糖核蛋白检测试剂盒 | Human Anti-Smith antigen/RNP (Sm/RNP) IgG ELISA kit | 3300-110-SRG |
RF (Rheumatoid Factors) | 人抗类风湿因子IgG检测试剂盒 | Human Rheumatoid Factors IgG (RF) ELISA Kit | 3000-110-RFG |
人抗类风湿因子IgM检测试剂盒(半定量) | Human Rheumatoid Factors IgM (RF) ELISA Kit Semi-Quantitative | 3000-100-RFM | |
人抗类风湿IgA检测试剂盒 | Human Rheumatoid Factors IgA (RF) ELISA Kit | 3000-105-RFA | |
小鼠抗类风湿因子总抗体检测试剂盒 | Mouse Rheumatoid Factor (RF) Ig's (total (A+G+M) ELISA kit | 6200 | |
小鼠抗胰岛素IgG检测试剂盒 | Mouse Anti-Insulin IgG ELISA Kit | 3700-MIG | |
小鼠抗IgM 检测试剂盒 | Mouse Anti-Insulin IgM ELISA Kit | 3710-MIM | |
大鼠抗IgM 检测试剂盒 | Rat Anti-Insulin IgM ELISA Kit | 3760-RIM |
自身抗原 | 中文名称 | 英文名称 | 货号 |
Anti-PCNA | 人抗增殖细胞抗原IgG检测试剂盒 | Human Anti-Proliferating Cell Nuclear Antigen (PCNA) IgG ELISA kit | 5020 |
Circulating immune complexes (CIC) | 小鼠循环免疫复合物总抗体检测试剂盒 | Mouse Circulating Immune Complexes (CIC) Ig's (total (A+G+M) ELISA kit | 5900 |
人抗C1q补体IgG检测试剂盒 | Human Anti-C1q IgG ELISA Kit | 2950 | |
Anti-Cyclic Citrullinated Peptide (CCP) | 人抗环瓜氨酸肽IgG ELISA 试剂盒 | Human Anti-Cyclic Citrullinated Peptide (CCP) IgG ELISA kit | 3300-340-CCG |
小鼠抗环瓜氨酸肽IgG 检测试剂盒 | Mouse Anti-Cyclic Citrullinated Peptide (Anti-CCP) IgG ELISA Kit | 680-400-CCG | |
小鼠抗环瓜氨酸肽IgM 检测试剂盒 | Mouse Anti-Cyclic Citrullinated Peptide (Anti-CCP) IgM ELISA Kit | 680-410-CCM | |
大鼠抗环瓜氨酸肽IgG 检测试剂盒 | Rat Anti-Cyclic Citrullinated Peptide (Anti-CCP) IgG ELISA Kit | 680-420-CCG | |
大鼠抗环瓜氨酸肽IgM检测试剂盒 | Rat Anti-Cyclic Citrullinated Peptide (Anti-CCP) IgM ELISA Kit | 680-430-CCM | |
Anti-Histones | 人抗组蛋白IgG检测试剂盒 | Human Anti-Histones IgG ELISA kit | 3300-130-HNG |
小鼠抗组蛋白IgG检测试剂盒 | Mouse Anti-Histones Ig's (total (A+G+M) ELISA Kit | 5610 | |
大鼠抗组蛋白IgG检测试剂盒 | Rat Anti-Histones IgG-specific ELISA Kit | 650-430-HIS | |
猴抗组蛋白IgG ELISA 试剂盒 | Monkey Anti-Histones IgG ELISA Kit | 670-120-HIM | |
Anti-Scl70 (Scleroderma 70 Kda) | 人抗硬皮病/DNA 拓扑异构酶IgG检测试剂盒 | Human Anti-Scl-70 (Scl70/Scleroderma 70 Kda/DNA-topoisomerase-1) IgG ELISA kit | 3300-140-SCG |
小鼠抗硬皮病总抗体检测试剂盒 | Mouse anti-Scl70 Ig's (total (A+G+M) ELISA Kit | 6110 | |
Anti-Jo-1 | 人抗Jo-1抗原IgG检测试剂盒 | Human Anti-Jo-1 (Scleroderma 70 Kda/DNA-topoisomerase-1) IgG ELISA kit | 3300-150-JOG |
小鼠抗Jo-1抗原总抗体检测试剂盒 | Mouse Anti-Jo-1 Ig's (total) ELISA Kit, 96 tests, Quantitative | 6005 | |
Anti-Fodrin | 人抗胞衬蛋白IgG检测试剂盒 | Human Anti-Alpha Fodrin IgG ELISA kit | 3300-160-AFG |
Anti-Cardiolipin | 人抗心磷脂IgG检测试剂盒 | Human Anti-Cardiolipin IgG ELISA kit | 3300-170-CLG |
人抗心磷脂IgM检测试剂盒 | Human Anti-Cardiolipin IgM ELISA kit | 3300-175-CLM |
自身抗原 | 中文名称 | 英文名称 | 货号 |
| 人抗心磷脂IgA检测试剂盒 | Human Anti-Cardiolipin IgA ELISA kit | 3300-185-CLA |
小鼠抗心磷脂总抗体检测试剂盒 | Mouse Anti-Cardiolipin Ig's (A+G+M) ELISA kit | 5510 | |
大鼠抗心磷脂总抗体检测试剂盒 | Rat Anti-Cardiolipin Ig's (A+G+M) ELISA kit | 5520 | |
Anti-Beta 2 Glycoprotein (B2GP) | 人抗β2糖蛋白IgG检测试剂盒 | Human Anti-Beta2-Glycoprotein 1 (B2GP1) IgG ELISA kit | 3300-190-B2G |
人抗β2糖蛋白IgM检测试剂盒 | Human Anti-Beta2-Glycoprotein 1 (B2GP1) IgM ELISA kit | 3300-195-B2M | |
人抗β2糖蛋白IgA检测试剂盒 | Human Anti-Beta2-Glycoprotein 1 IgA ELISA kit | 3300-200-B2A | |
Anti-Phospholipid Screen | 人抗磷脂抗体IgG/IgM试剂盒 | Human Anti-Phospholipid Screen IgG/IgM ELISA kit | 3300-200-APS |
Anti-Phosphotidyl Serine | 人抗磷酯酰丝氨酸IgG/IgM试剂盒 | Human Anti-Phosphatidyl serine IgG/IgM ELISA kit | 3300-210-PSS |
Anti-Phosphotidyl Inositol | 人抗磷酯酰肌醇IgG/IgM 检测试剂盒 | Human Anti-Phosphotidyl Inositol IgG/IgM ELISA kit | 3300-215-PIS |
Anti-Phosphotidic Acid | 人抗磷脂酸IgG/IgM检测试剂盒 | Human Anti-Phosphotidic Acid IgG/IgM ELISA kit | 3300-220-PAS |
人抗磷脂酸IgG检测试剂盒 | Human Anti-Phosphocholine (anti-PC) IgG ELISA Kit | 680-300-PCG | |
Anti-Phosphocholine (PC)
| 人抗磷酸胆碱IgM检测试剂盒 | Human Anti-Phosphocholine (anti-PC) IgM ELISA Kit | 680-310-PCM |
小鼠抗磷酸胆碱IgG检测试剂盒 | Mouse Anti-Phosphocholine (anti-PC) IgG ELISA Kit | 680-100-PCG | |
小鼠抗磷酸胆碱IgM检测试剂盒 | Mouse Anti-Phosphocholine (anti-PC) IgM ELISA Kit | 680-110-PCM | |
大鼠抗磷酸胆碱IgG检测试剂盒 | Rat Anti-Phosphocholine (anti-PC) IgG ELISA Kit | 680-200-PCG | |
大鼠抗磷酸胆碱IgM检测试剂盒 | Rat Anti-Phosphocholine (anti-PC) IgM ELISA Kit | 680-210-PCM | |
Anti-Prothrombin | 人抗凝血素IgG/IgM检测试剂盒 | Human Anti-Prothrombin IgG/IgM ELISA kit | 3300-230-APG |
人抗凝血素IgA检测试剂盒 | Human Anti-Prothrombin IgA ELISA kit | 3300-235- APA | |
Anti-Annexin V | 人抗膜联蛋白V | Human Anti-Annexin V IgG ELISA kit | 3300-240-AVA |
Anti-Neutrophil Cytoplasmic Antibody (ANCA ) Screen | 人抗中性粒细胞细胞质PR3/MPO IgG检测试剂盒 | Human ANCA Screen (Anti-PR3 and Anti-MPO) IgG ELISA kit | 3300-250-ANG |
自身抗原 | 中文名称 | 英文名称 | 货号 |
ANCA (Anti-PR3) | 人抗中性粒细胞细胞质PR3 IgG检测试 | Human ANCA (Anti-PR3) IgG ELISA kit | 3300-255-PRG |
ANCA (Anti-MPO) | 人抗中性粒细胞细胞质MPO IgG检测试剂盒 | Human ANCA (Anti-MPO) IgG ELISA kit | 3300-265-MPG |
Anti-glomerular basement membrane (GBM) | 人抗肾小球基底膜IgG检测试剂盒 | Human Anti-glomerular basement membrane (GBM) IgG ELISA kit | 3300-270-GBG |
Anti- bactericidal permeability increasing (BPI) | 人抗杀菌渗透增强蛋白 IgG检测试剂盒 | Human Anti-bactericidal permeability increasing (BPI) protein IgG ELISA kit, | 3300-280-BPG |
Anti-Elastase | 人抗弹性蛋白酶IgG检测试剂盒 | Human Anti-Elastase IgG ELISA kit | 3300-290-ELG |
Anti-Gliadin | 人抗醇溶蛋白IgG检测试剂盒 | Human Anti-Gliadin IgG ELISA kit | 3300-300-GLG |
人抗醇溶蛋白IgM检测试剂盒 | Human Anti-Gliadin IgM ELISA kit | 3300-305-GLM | |
人抗醇溶蛋白IgA检测试剂盒 | Human Anti-Gliadin IgA ELISA kit | 3300-310-GLA | |
Anti-Parietal Cell | 人抗旁细胞IgG检测试剂盒 | Human Anti-Parietal cell (alpha and beta subunits of the Parietal Cell (H//K/ATPase) IgG ELISA kit | 3300-315-PRG |
ASCA (anti-S. cerevisiae Antibodies or anti-mannan) | 人抗酿酒酵母IgA/IgG 检测试剂盒 | Human Anti-ASCA (mannan from Saccharomyces cerevisiae) IgA/IgG ELISA kit | 3300-320-ASC |
人抗酿酒酵母IgG 检测试剂盒 | Mouse Anti-ASCA (anti-S. cerevisiae Antibodies or anti-mannan) IgG ELISA Kit | 680-500-ASG | |
人抗酿酒酵母IgM 检测试剂盒 | Mouse Anti-ASCA (anti-S. cerevisiae Antibodies or anti-mannan) IgM ELISA Kit | 680-505-ASM | |
小鼠抗酿酒酵母IgA 检测试剂盒 | Mouse Anti-ASCA (anti-S. cerevisiae Antibodies or anti-mannan) IgA ELISA Kit | 680-510-ASA | |
大鼠抗酿酒酵母IgG 检测试剂盒 | Rat Anti-ASCA (anti-S. cerevisiae Antibodies or anti-mannan) IgG ELISA Kit | 680-520-ASG | |
大鼠抗酿酒酵母IgM 检测试剂盒 | Rat Anti-ASCA (anti-S. cerevisiae Antibodies or anti-mannan) IgM ELISA Kit | 680-525-ASM | |
大鼠抗酿酒酵母IgA 检测试剂盒 | Rat Anti-ASCA (anti-S. cerevisiae Antibodies or anti-mannan) IgA ELISA Kit | 680-530-ASA |
